Mayiladuthurai is well-connected by road and rail with the rest of India. The nearest international airport is at Tiruchirapalli, which is 130 kilometres from Mayiladuthurai while the nearest seaport is at Nagapattinam which is 52 kilometres away. The State Highways SH-23 and SH-64 pass through Mayiladuthurai. There are regular bus services to important cities in Tamil Nadu. There are also regular services to other South Indian cities as Bangalore, Tirupathi and Thiruvananthapuram. Mayiladuthurai forms a part of the Division 1 of the Tamil Nadu State Transport Corporation which is headquartered at Kumbakonam. The town's principal bus station is located on the SH-64 State Highway.